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Custom Peptide Synthesis

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Custom RNA,DNA Cynthesis

Based on the core technologies of the RNA,DNA monomer synthesis, the modified siRNA,DNA oligo synthesis and the fluorescent labeling ,Hanhong provide whole-angle custom DNA,RNA synthesis,. Low price, high quality and quick deliver is our advantage.

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With strong research and production teams equipped with top quality facilities , we can provide Custom Synthesis products from grams, kilograms to tons, especially heterocyclic building blocks and chiral chemicals.

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Synthesis of Unnatural Chiral α–Amino Acids

Author:N/A    | Post time:2014-11-26

The use of ligands to tune the reactivity and selectivity of transition metal catalysts for C(sp3)–H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we report a rare example of catalyst-controlled C(sp3)–H arylation using pyridine and quinoline derivatives: The former promotes exclusive monoarylation, whereas the latter activates the catalyst further to achieve diarylation. Successive application of these ligands enables the sequential diarylation of a methyl group in an alanine derivative with two different aryl iodides, affording a wide range of β-Ar-β-Ar′-α–amino acids with excellent levels of diastereoselectivity (diastereomeric ratio > 20:1). Both configurations of the β-chiral center can be accessed by choosing the order in which the aryl groups are installed. The use of a quinoline derivative as a ligand also enables C(sp3)–H olefination of a protected alanine.

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